According to Monday’s study, women with BRCA1 mutations should have preventive ovarian surgery– known as prophylactic oophorectomy – by age 35, as waiting appears to increase the risk of ...

BRCA1 belongs to a family of tumor suppressor genes, which make proteins that mend damaged DNA. Generally, a single functioning copy of a gene is sufficient to ensure normal function even when the ...

The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer. Now, Shuklaet al.demonstrate that mice lacking BRCA1 in cardiomyocytes are more sensitive to ischaemia than control ...

The tumour suppressor breast and ovarian cancer type 1 susceptibility protein (BRCA1) is integral for the maintenance of genome stability through its roles in cell cycle checkpoint control and DNA ...

The full name of the BRCA1 gene is “breast cancer 1, early onset” and it codes for a tumor suppressor protein. This article explores the gene function of the BRCA1 gene.

Learning I carried the BRCA1 mutation was terrifying, but it gave me the power to choose prevention, embrace survivorship, ...

Breast cancer survivor Christina Applegate announced that she had her ovaries and fallopian tubes removed because she has the BRCA1 mutation — should you get tested? In 2008, Christina Applegate ...

BRCA1 variants, on the other hand, don't seem to be major contributors to disease initiation or progression, with only 1 somatic variant and 1 germline variant found in combination with a ...

BRCA1 or BRCA2 genes are more common in young women, and these mutations increase cancer risk by as much as 84%. Six percent of all breast cancer patients carry BRCA gene mutations, but in ...

A method for detecting a germline alteration in a BRCA1 gene, said alteration selected from the group consisting of the alterations set forth in Tables 11 and 12 which comprises analyzing a ...

Studies of the association between OCP use and BC risk for BRCA1 and BRCA2 mutation carriers have assessed ever use rather than current use, and the findings are conflicting. 7–18 Although most ...

It's a gene commonly associated with breast cancer in women, but in fact men who carry certain mutations in their BRCA1 or BRCA2 genes are at higher risk of developing certain types of cancer ...