In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone ...

This editorial explains the genetic basis of Pompe’s disease and other lysosomal storage disorders, as well as the foundations of enzyme-replacement therapy.

A 14-year-old boy who lived on a farm presented with episodic headaches associated with vomiting. MRI showed a large, multiloculated cyst in the brain, and a craniotomy (shown in a video) was perfo ...

The author describes the scientific foundations and implications of a study on variant EPO and erythrocytosis.

A 4-year-old boy had a 2-day history of right hip pain and limping. A radiograph showed a focal area of collapse in the right femoral head.

Among women with a history of early breast cancer treated with endocrine therapy (tamoxifen or aromatase inhibitors), vasomotor symptoms are common, occurring in up to 90% of this population, and o ...

The landscape for genetically modified organisms is changing, thanks to sharp increases in the amounts and numbers of chemical herbicides applied to GM crops and the classification of two of the mo ...

The U.S. Supreme Court recently upheld Tennessee’s ban on gender-affirming hormonal treatment for transgender minors. This decision will have profound implications.

Large B-cell lymphoma (LBCL) spans the gamut of aggressive lymphoid tumors with extensive biologic and clinical heterogeneity. Most patients with LBCL are cured with the use of front-line chemoimmu ...

As her patients near the end of life, an infectious disease physician who knows their stories sometimes needs to step out of her proverbial lane to help them assess and achieve their goals of care.

To the Editor: The review article by Fasano (Jan. 23 issue)1 concerning human nutrition and hunger regulation omits the crucial role of autophagy, a cellular recycling process vital for maintaining ...

The Supreme Court recently agreed to hear a case about adolescent e-cigarette use and the FDA’s role in addressing it. A ruling against the FDA could have implications for its authority and for ...