The hour-long show, titled An Oprah Winfrey Special: The Menopause Revolution, is set to air March 31. It will feature Winfrey speaking with medical experts, celebrities — including Halle Berry, Naomi Watts and Maria Shriver — and everyday women about their experiences with perimenopause and menopause.

As women strive to understand and openly discuss the changes that impact every cell of their bodies, and new research shows women as young as 35 starting to show symptoms of perimenopause, Winfrey brings together a panel of renowned medical experts and leading voices to discuss the traditionally taboo topic of menopause before a live studio audience.

Oprah is no stranger to unpacking important topics, especially those relating to women’s health. In 2023, Oprah shed light on a life stage that all women experience, menopause, hosting her groundbreaking conversation “The Menopause Talk.