Women with BRCA1 mutations should remove their ovaries by age 35, according to a study that published online Monday.

The research, published in Nature Communications, suggests this preemptive, two-part approach could be the most effective plan of treatment for early-stage breast cancer linked to BRCA1 and BRCA2 ...

Doctors have long recognized that women with mutations in two particular genes – BRCA1 and BRCA2 – have a higher risk of breast and ovarian cancer.

BRCA1 is one of the best-studied cancer genes in the world. Still, on occasion, doctors will test a patient and find a BRCA1 mutation no one has ever seen before. This creates a dilemma. The newly ...

We present data showing that BRCA1 ubiquitinates G2/M cell cycle proteins, cyclin B and Cdc25C, leading to their accelerated degradation via a mechanism that is independent of APC/C. BRCA1 ...

The BRCA1 gene is located on the long arm of chromosome 17, at position 17q21. The gene spans around 100 kilobases and codes for a protein containing 1863 amino acids.

Although BRCA1-driven triple negative breast cancer is known to arise from these stem cells, how they develop as a result of the mutation has been poorly understood.

In fact, BRCA1 is a tumor-suppressor gene because of it's ability to guide the repair of damaged DNA. Only when it is mutated does it allow cancer to occur with increased frequency.

Christina Applegate announced she had her ovaries and fallopian tubes removed because she has the BRCA1 mutation — should you get tested?

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression.

To test the hypothesis that altered expression of BRCA1 protein may play an important role in sporadic breast cancer development, 50 randomly selected primary breast cancers (frozen sections, 5 ...

Long known to be associated with breast and ovarian cancers, the BRCA1 protein may also be linked to Alzheimer's disease.