In recent years, CryoEM has enabled scientists to decipher the structures of the fibrils that form various deposits in neurodegenerative disease. They have not only solved disease-specific folding ...

Polyphosphate chains play an important physiological role in many organisms, for example to ensure cell growth even under deficiency conditions. Chemists and biochemists have now gained insight into ...

Amyloid fibrils appear in many neurodegenerative diseases, and scientists are eager to understand how they form and spread. But amyloids—clumped aggregations of misfolded proteins—can be difficult to ...

Research led by the University of Michigan has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer's, Parkinson's and other ...

Research led by the University of Michigan has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer’s, Parkinson’s and other ...

Recent work has shown that acidocalcisomes, which are electron-dense acidic organelles rich in calcium and polyphosphate, are the only organelles that have been conserved during evolution from ...

Inorganic polyphosphate (polyP) is a ubiquitous, evolutionarily conserved polymer composed of linear chains of inorganic phosphate residues. Long recognised as an energy metabolite and phosphate ...