NFL Week 16 betting spreads, lines, point totals for every game on NFL Week 16 schedule, with odds for favorites and underdogs in each NFL matchup.

NFL Week 16 picks, predictions, win probabilities for Buccaneers-Panthers, Jets-Saints, Vikings-Giants, Falcons-Cardinals, Steelers-Lions, more games.

We’re down to the last three weeks of the NFL season, so we’re starting to see the rankings settle a bit. This week’s top-10 list has a new player in the mix, and we’ve seen a bit of a shakeup in the ...

Ranking the best and most underrated NFL defenses to play as fantasy football D/ST units in Week 16 of the 2025 NFL season ...

Quinshon Judkins suffered the biggest injury of the week in the second quarter of the Cleveland Browns’ matchup with the ...

It’s been a long 2025 NFL season so far with twists, turns, shocking injuries, surprising contenders and disappointing years ...

The NFL playoff picture continues to take shape in the NFC in Week 17 on Dec. 20 as two Saturday games could decide two ...

Who will win the Bucs vs. Panthers NFC South showdown? USA TODAY Sports provides the early predictions for every NFL Week 16 game.

NFL Week 16 has arrived and we asked USA TODAY Sports' staff for their top bets for the entire NFL slate. Here are their picks and predictions.

You want upsets? We've got upsets. Multiple underdogs took down the favorite in Week 16 of the 2025 NFL season. Keep reading to find a comprehensive list of the teams that defied the odds. FOX Sports ...

Workhorse Christian McCaffrey of the 49ers leads the league in touches per game (24.64) and is third in yards from scrimmage with 1,742. Thearon W. Henderson / Getty Images Editor’s note: Every week, ...

We've reached Week 16, so some teams are clinching playoff spots, some are aiming to stave off elimination and others are just playing out the string while keeping one eye on the NFL Draft order. And, ...