In certain contexts, the Notch receptor may participate in “reverse signaling,” influencing neighboring cells directly.

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a ...

Calcium is widely known for its role in maintaining strong bones and teeth, but it is also one of the body's most important ...

Medical biochemistry unravels the molecular foundations of health and disease by examining small-molecule metabolism, enzyme function and cellular signalling. Metabolomics extends this enquiry by ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

Glyn Dawson, an expert on lipid biochemistry and longtime professor in the Departments of Pediatrics and Biochemistry and ...

Researchers have shown that the formation of biological condensates affects cellular activity far beyond their immediate vicinity. The results show that they may be a previously missing mechanism by ...