FIC1 disease collectively refers to a group of autosomal-recessive familial liver disorders characterized by intrahepatic cholestasis due to mutations in the ATP8B1 gene (initially named FIC1).

Cholestatic liver diseases (CLDs) are a group of disorders characterized by the impairment of bile formation, secretion, or excretion. This impairment leads to bile acid accumulation in the liver, ...

Chronic cholestasis, defined as the impairment of bile acid formation and/or flow persisting for more than six months, encompasses a broad spectrum of hepatobiliary disorders, both heritable and ...

Age, female gender and obesity are well-known risk factors for cholesterol gallstone disease, which has an incidence of up to 15% in the Western world. The association between gallstones and obesity ...

The gall bladder is seldom brought up in conversation until it is out of order. This little, pear-shaped organ lies just under the liver and is the ma.

Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and gallbladder inflammation. Here, we describe the ...

Stage 4 bile duct cancer is the most advanced stage of this disease. Treatment involves managing symptoms and improving quality of life. Bile duct cancer is a rare type of cancer that affects the bile ...